Influence of the naturally occurring human CASP1 variant L265S on subcellular distribution and pyroptosis
نویسندگان
چکیده
Introduction Patients with unexplained recurrent febrile episodes and CASP1 variants suffer from systemic sterile inflammation despite altered enzymatic activity of procaspase-1 and reduced IL-1b release. Most recent findings from our group indicate that the proinflammatory effects of CASP1 variants with reduced or abrogated enzymatic activity could be due to receptor interacting protein kinase 2 (RIP2) mediated increase of NF-kB activation. These findings are additionally supported by a trend to elevated IL-6 and TNF-a expression in patients with CASP1 variants.
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2015